https://www.fearsteve.com/health/can-hrt-cause-anxiety-signs-triggers-and-treatment-options/ The relationship between estradiol and anxiety HRT is especially relevant during perimenopause, when estrogen levels may fluctuate significantly. Estradiol treatment may help some women manage menopause-related symptoms, particularly hot flashes and night sweats. When these symptoms improve, sleep and overall quality of life may improve as well. Fri, 13 Nov 2026 21:49:16 UTC en