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Acteria were removed, and hydrolysis of the substrate was measured at 405 nm. As a positive control, purified SK (pSK) was incubated in plasma, and the substrate was added directly. The results are shown as the means of at least three independent experiments with fresh frozen plasma from different donors the SD. n.s., not significant; **, P 0.01; ***, P 0.001; ****, P 0.0001.creased PK/FXIIa activ

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